Considering the extensive diversity of formulations marketed for joint health in companion animals, I am interested in discussing the comparative efficacy of various ingredients commonly found in these supplements. Specifically, how do compounds such as glucosamine hydrochloride/sulfate, chondroitin sulfate, methylsulfonylmethane (MSM), and omega-3 fatty acids perform either individually or synergistically in maintaining joint function and slowing the progression of degenerative joint disease? Additionally, which biomarkers or imaging modalities have proven most reliable in evaluating the therapeutic outcomes associated with these supplements in clinical settings? Insights from both controlled studies and field observations would be highly valuable in elucidating optimal strategies for joint support in pets.