I am investigating the potential metabolic interactions between the active compounds in Revolution flea treatment and various dietary formulations administered to companion animals. Specifically, I would like to know if the topical administration of selamectin (the active ingredient in Revolution) has any documented impact on the absorption or metabolism of nutrients, particularly fat-soluble vitamins or other micronutrients. Furthermore, are there any studies or case reports indicating that concurrent administration with certain dietary components might modulate the pharmacokinetics of selamectin in either felines or canines? A mechanistic discussion supported by recent literature would be appreciated.